CD206

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone MR5D3
Applications FC
Amount 0.025 mg
ArtNr 20-783-310287
Available
Genway ID:
GWB-A50549
Specificity:
CD206NCBI
Gene ID:
17533
Specificity:
CD206
Clone:
MR5D3
Immunogen:
Chimaeric CRD4-7-Fc protein.
Fusion Partner:
Spleen cells from immunised Fischer rats were fused with cells of the Y3 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat
Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria fungi and other pathogens.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Miscellaneous:
CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4 5 and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.
Similarity:
Contains 8 C-type lectin domains.
Similarity:
Contains 1 fibronectin type-II domain.
Similarity:
Contains 1 ricin B-type lectin domain. 1. Martinez-Pomares. L. et al. (2003) Analysis of mannose receptor regulation by IL-4. IL-10 and proteolytic processing using novel monoclonal antibodies. 2. Zamze. S. et al. (2002) Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptor.
Amount: 0.025 mg
Available: In stock
Listprice: €218.13
Discount: -10.0%
Price: €196.32
You save: €21.81
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