Antibodies

CD101

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone BB27
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310290
Available
Genway ID:
GWB-9F5A40
Specificity:
CD101NCBI
Gene ID:
9398
Specificity:
CD101
Clone:
BB27
Immunogen:
Human thymic clone B12
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/50 - 1/100
Function:
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
Expressed in lung thymus and small intestine. Detected in cutaneous dendritic cells activated T-cells monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells the CD4(+) CD56(+) blastic tumor cells as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients.
Ptm:
N-glycosylated.
Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains. 1. Bagot. M. et al. (1997) CD101 is expressed by skin dendritic cells. Role in T-lymphocyte activation
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Price: €152.38
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