CD283

CD283NCBI

IgG1

Ba/F3 cells transfected with human TLR3 (CD283).

This product recognises human and canine TLR3 otherwise known as CD283. TLR3 is a member of the Toll-like receptor (TLR) family and functions as a receptor for double-stranded (ds) RNA. TLRs are expressed on the cell surface and the endocytic compartment and recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents. They also initiate cell signalling to induce production of cytokines necessary for the innate immunity and subsequent adaptive immunity. Cell surface expression of TLR3 has been reported on MRC-5 fibroblasts (1) and this antibody has been shown to suppress poly (I) : poly C mediated IFN beta production by these cells.

Flow Cytometry - 1/10 - 1/50Western Blotting - 1/100 - 1/1000

Binds MYD88 via their respective TIR domains (By similarity). Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3 signaling. Binding of ds-RNA is required for the interaction with SRC.

Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes including monocyte precursors.

Belongs to the Toll-like receptor family.

Contains 1 TIR domain. 1. Matsumoto. M. et al. (2002) Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.