« Back
Home /
DESMOGLEIN 3

DESMOGLEIN 3


Manufacturer	GENWAY
Category	Oncology Antibodies Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Specific against	other
Clone	5G11
Applications	WB, IP, IHC
Amount	0.025 mg
Item no.	20-783-310316
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-4029FF
Specificity:	DESMOGLEIN 3NCBI
Gene ID:	1830
Specificity:	DESMOGLEIN 3
Clone:	5G11
Immunogen:	Recombinant human desmoglein 3
Fusion Partner:	Spleen cells from immunised Balb/c mice were fused with cells of the mouse NS-1 myeloma cell line.
Immunohistology:	This product requires antigen retrieval using heat treatment methods followed by protein digestion of paraffin embedded sections eg. trypsin prior to staining. Histology: Skin
Buffer Solution:	Phosphate buffered saline
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Dilution:	Suggested
Dilution:	Western Blotting - 1/100 - 1/1000
Function:	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Location:	Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction desmosome (By similarity).
Tissue Specificity:	Epidermis tongue tonsil esophagus and carcinomas.
Domain:	Calcium may be bound by the cadherin-like repeats (Potential).
Disease:	Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.
Similarity:	Contains 4 cadherin domains. 1. Wahl. J. et al. (2002) Generation of monoclonal antibodies specific for desmoglein family members. 2. Koch. P. J. et al. (1998) Desmoglein 3 anchors telogen hair in the follicle.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.025 mg

available

Delivery expected until 5/30/2024