DESMOGLEIN 3

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 5G11
Applications WB, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310316
Available
Genway ID:
GWB-4029FF
Specificity:
DESMOGLEIN 3NCBI
Gene ID:
1830
Specificity:
DESMOGLEIN 3
Clone:
5G11
Immunogen:
Recombinant human desmoglein 3
Fusion Partner:
Spleen cells from immunised Balb/c mice were fused with cells of the mouse NS-1 myeloma cell line.
Immunohistology:
This product requires antigen retrieval using heat treatment methods followed by protein digestion of paraffin embedded sections eg. trypsin prior to staining. Histology: Skin
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Dilution:
Suggested
Dilution:
Western Blotting - 1/100 - 1/1000
Function:
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction desmosome (By similarity).
Tissue Specificity:
Epidermis tongue tonsil esophagus and carcinomas.
Domain:
Calcium may be bound by the cadherin-like repeats (Potential).
Disease:
Pemphigus vulgaris (PV) is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion caused by the action of autoantibodies against desmoglein 3.
Similarity:
Contains 4 cadherin domains. 1. Wahl. J. et al. (2002) Generation of monoclonal antibodies specific for desmoglein family members. 2. Koch. P. J. et al. (1998) Desmoglein 3 anchors telogen hair in the follicle.
Amount: 0.025 mg
Available: In stock
Listprice: €212.88
Discount: -10.0%
Price: €191.59
You save: €21.29
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