Antibodies

CD147

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone OX114
Applications FC
Amount 25 TESTS
ArtNr 20-783-310323
Available
Genway ID:
GWB-6AF684
Specificity:
CD147NCBI
Gene ID:
12215
Specificity:
CD147
Clone:
OX114
Immunogen:
Fusion protein mCD147dO-2rCD4d3+4
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat - 1/5
Function:
Plays pivotal roles in spermatogenesis embryo implantation neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1 SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro promotes outgrowth of astrocytic processes (By similarity).
Subunit:
Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2 MAG and L1CAM (By similarity). Interacts with AJAP1.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Tissue Specificity:
Present only in vascular endothelium in non-neoplastic regions of the brain whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Induction:
Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.
Ptm:
N-glycosylated.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Hanna. S. M. et al. (2003) A novel form of the membrane protein CD147 that contains an extra Ig-like domain and interacts homophilically.
Amount: 25 TESTS
Available: In stock
Listprice: €212.88
Discount: -10.0%
Price: €191.59
You save: €21.29
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