CD18

CD18

M18/2

Spleen cells from immunised Wistar - Furth rats were fused with cells of the mouse P3X63Ag8. 653 myeloma cell line.

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

Integrin alpha-L/beta-2 is a receptor for ICAM1 ICAM2 ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.

Membrane; Single-pass type I membrane protein.

Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.

Contains 1 VWFA domain. 1. Sanchez-Madrid. F. et al. (1983) Mapping of antigenic and functional epitopes on the alpha - and beta-subunits of two related mouse glycoproteins involved in cell interactions. LFA-1 and MAC-1. 2. Zahalka. M. A. et al. (1993) Blocking Lymphoma Invasiveness with a Monoclonal Antibody Directed against the Beta-Chain of the Leukocyte Adhesion Molecule (CD18). 3. Driessens. M. H. et al. (1996) Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1. -2 and -3 are distinct. J. Leukoc. Biol. 60:758-765.