Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
9C10 (MFR. 4 |
Applications |
FC, IHC |
Amount |
0.025 mg |
Item no. |
20-783-310345 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Genway ID: |
GWB-57244D |
Specificity: |
CD49dNCBI |
Gene ID: |
16401 |
Specificity: |
CD49d |
Clone: |
9C10 (MFR. 4. B) |
Immunogen: |
Mouse LyD9 haematopoietic progenitor cells |
Fusion Partner: |
Spleen cells from immunised Lewis rat were fused with cells of the mouse P3X63Ag8. 653 myeloma cell line. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium AzideSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul Suggested |
Dilution: |
Flow Cytometry - 1/10 - 1/50 |
Function: |
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. |
Subunit: |
Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. |
Subcellular Location: |
Membrane; Single-pass type I membrane protein. |
Domain: |
The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion. |
Ptm: |
Phosphorylation on Ser-1027 inhibits PXN binding. |
Similarity: |
Belongs to the integrin alpha chain family. |
Similarity: |
Contains 7 FG-GAP repeats. 1. Kinashi. T. et al. (1994) Adhesion Molecules in Hematopoietic Cells. |
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