CD49e


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Adhesion Molecules Antibodies By Cell Type Flow Cytometry Immunohistochemistry Primary Antibodies
Type	Antibody
Specific against	other
Clone	MFR5 (5H10)
Applications	FC, IHC
Amount	0.025 mg
Item no.	20-783-310346
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-79E3DD
Specificity:	CD49eNCBI
Gene ID:	16402
Specificity:	CD49e
Clone:	MFR5 (5H10)
Immunogen:	Mouse MC/9 cell line
Fusion Partner:	Spleen cells from immunised Lewis rats were fused with cells of the Murine P3X63Ag8. 653
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium AzideSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ml. Suggested
Dilution:	Flow Cytometry - 1/10 - 1/25
Function:	Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\' s sarcoma lesions.
Subunit:	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats. 1. Kinashi. T. and Springer. T. A. (1994) Adhesion Molecules in Hematopoietic cells. 2. Van der Loo. J. C. M. et al. (1998) VLA-5 Is Expressed by Mouse and Human Long-term Repopulating Hematopoietic Cells and Mediates Adhesion to Extracellular Matrix Protein Fibronectin. 3. Cukierman. E. et al. (2001) Taking Cell-Matrix adhesions to the Third Dimension.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 0.025 mg

available

Delivery expected until 5/9/2024