Antibodies

CD106

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone MVCAM A (429)
Applications FC
Amount 0.025 mg
ArtNr 20-783-310350
Available
Genway ID:
GWB-44C03D
Specificity:
CD106NCBI
Gene ID:
22329
Specificity:
CD106
Clone:
MVCAM A (429)
Immunogen:
Stromal cell line PA6
Fusion Partner:
Spleen cells from immunised Lewis rats were fused with cells of the mouse P3X63Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - 1/5 - 1/10
Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:
Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity).
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed on inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Induction:
By cytokines (e. g. IL-1 TNF-alpha).
Domain:
Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Ptm:
Sialoglycoprotein.
Disease:
May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains. 1. Kinashi. T. and Springer. T. A. (1994) Adhesion molecules in hematopoietic cells. 2. Wormley. F. L. et al. (2001) Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis.
Amount: 0.025 mg
Available: In stock
Listprice: €182.24
Price: €182.24
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