CD106


Manufacturer	GENWAY
Category	Oncology Neuroscience Neuroinflammation Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies By Organ Renal Cancer
Type	Antibody
Specific against	other
Clone	MVCAM A (429)
Applications	FC
Amount	25 TESTS
Item no.	20-783-310351
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-251970
Specificity:	CD106NCBI
Gene ID:	22329
Specificity:	CD106
Clone:	MVCAM A (429)
Immunogen:	Stromal cell line PA6
Fusion Partner:	Spleen cells from immunised Lewis rats were fused with cells of the mouse P3X63Ag8. 653 myeloma cell line.
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:	Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Expressed on inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Induction:	By cytokines (e. g. IL-1 TNF-alpha).
Domain:	Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Ptm:	Sialoglycoprotein.
Disease:	May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
Similarity:	Contains 7 Ig-like C2-type (immunoglobulin-like) domains. 1. Kinashi. T. and Springer. T. A. (1994) Adhesion molecules in hematopoietic cells. 2. Wormley. F. L. et al. (2001) Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis.

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Amount: 25 TESTS

available

Delivery expected until 5/9/2024