Antibodies

CD88

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone 20/70
Applications FC
Amount 25 TESTS
ArtNr 20-783-310484
Available
Genway ID:
GWB-6D81E7
Specificity:
CD88
Specificity:
CD88
Clone:
20/70
Immunogen:
RBL-2H3 transfected cells expressing murine C5aR.
Fusion Partner:
Cells from immunised Lou/c were fused with cells of the X63-Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis granule enzyme release and superoxide anion production.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Ptm:
Sulfation plays a critical role in the association of the receptor with C5a but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.
Similarity:
Belongs to the G-protein coupled receptor 1 family [view classification]. 1. Soruri. A. et. al. (2003) Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody. 2. Godau. J. et. al. (2004) C5a initiates the inflammatory cascade in immune complex peritonitis. 3. Baelder. R. et. al. (2005) Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppress airway hyperresponsiveness and airway inflammation.
Amount: 25 TESTS
Available: In stock
Listprice: €212.88
Price: €212.88
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