CD86

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone PO3
Applications FC
Amount 25 TESTS
ArtNr 20-783-310497
Available
Genway ID:
GWB-55F153
Specificity:
CD86NCBI
Gene ID:
12524
Specificity:
CD86
Clone:
PO3
Immunogen:
Mouse B-cell line BCL1.
Fusion Partner:
Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3U1 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters and thus acts as a negative regulator of T-cell activation.
Subunit:
Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed by activated B-lymphocytes and monocytes.
Ptm:
Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Jin. J. P. et al. (2004) Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings. 2. Nozawa. K. et al. (2001) Preferential blockade of CD8+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases. 3. Nakajima. A. et al. (1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.
Amount: 25 TESTS
Available: In stock
Listprice: €212.88
Discount: -10.0%
Price: €191.59
You save: €21.29
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