CD86

CD86NCBI

CD86

Mouse B-cell line BCL1.

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters and thus acts as a negative regulator of T-cell activation.

Membrane; Single-pass type I membrane protein.

Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.

Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Jin. J. P. et al. (2004) Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings. 2. Nozawa. K. et al. (2001) Preferential blockade of CD8+ T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases. 3. Nakajima. A. et al. (1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.