Manufacturer |
GENWAY
|
Category |
|
Type |
Antibody |
Specific against |
other |
Clone |
3D7 |
Applications |
FC |
Amount |
0.025 mg |
Item no. |
20-783-310518 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Genway ID: |
GWB-5FEB94 |
Specificity: |
EMR3 |
Specificity: |
EMR3 |
Clone: |
3D7 |
Immunogen: |
ARHO-EMR3-CD97 (EGF1) transfectants. |
Fusion Partner: |
Spleen cells from immunised Armenian hamster were fused with cells of the mouse SP2/0 myeloma cell line. |
Preparation: |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
Buffer Solution: |
Phosphate buffered saline pH7. 4 |
|
Preservative Stabilisers: |
| 0. 09%Sodium AzideSuggested |
Flow Cytometry: |
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested |
Dilution: |
Flow Cytometry - Neat - 1/10 |
Function: |
Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils. |
Subunit: |
Forms a heterodimer consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity). |
Subcellular Location: |
Cell membrane; Multi-pass membrane protein. |
Subcellular Location: |
EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted extracellular space. Note=A soluble form is also detected (alpha subunit). |
Tissue Specificity: |
Displays a predominantly leukocyte-restricted expression with highest levels in neutrophils monocytes and macrophages. |
Ptm: |
Proteolytically cleaved into 2 subunits an extracellular alpha subunit and a seven-transmembrane subunit (By similarity). |
Similarity: |
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification]. |
Similarity: |
Contains 2 EGF-like domains. |
Similarity: |
Contains 1 GPS domain. 1. Stacey. M. et al. (2001) Human epidermal growth factor (EGF) module-containg mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognises a ligand on human macrophages and activated neutrophils. 2. Matmati. M. et al. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.