EMR3

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 3D7
Applications FC
Amount 0.025 mg
ArtNr 20-783-310518
Available
Genway ID:
GWB-5FEB94
Specificity:
EMR3
Specificity:
EMR3
Clone:
3D7
Immunogen:
ARHO-EMR3-CD97 (EGF1) transfectants.
Fusion Partner:
Spleen cells from immunised Armenian hamster were fused with cells of the mouse SP2/0 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils.
Subunit:
Forms a heterodimer consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) (By similarity).
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Subcellular Location:
EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted extracellular space. Note=A soluble form is also detected (alpha subunit).
Tissue Specificity:
Displays a predominantly leukocyte-restricted expression with highest levels in neutrophils monocytes and macrophages.
Ptm:
Proteolytically cleaved into 2 subunits an extracellular alpha subunit and a seven-transmembrane subunit (By similarity).
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily [view classification].
Similarity:
Contains 2 EGF-like domains.
Similarity:
Contains 1 GPS domain. 1. Stacey. M. et al. (2001) Human epidermal growth factor (EGF) module-containg mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognises a ligand on human macrophages and activated neutrophils. 2. Matmati. M. et al. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.
Amount: 0.025 mg
Available: In stock
Listprice: €182.24
Discount: -10.0%
Price: €164.02
You save: €18.22
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