Antibodies

CD282

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone 11G7
Applications FC
Amount 0.025 mg
ArtNr 20-783-310525
Available
Genway ID:
GWB-5B2F85
Specificity:
CD282
Specificity:
CD282
Clone:
11G7
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide (NaN3)1%Bovine Serum Albumin Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6 leading to NF-kappa-B activation cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2) soluble tuberculosis factor (STF) phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
Subunit:
Interacts with LY96 TLR2 and TLR6 via the extracellular domain. Binds MYD88 via their respective TIR domains. Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1.
Subcellular Location:
Membrane; Single-pass type I membrane protein (By similarity).
Tissue Specificity:
Highly expressed in peripheral blood leukocytes in particular in monocytes in bone marrow lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
Ptm:
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
Polymorphism:
Genetic variations in TLR2 are associated with suceptibility to leprosy [MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1 but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.
Similarity:
Belongs to the Toll-like receptor family.
Similarity:
Contains 14 LRR (leucine-rich) repeats.
Similarity:
Contains 1 TIR domain. 1. Sandor. F. et al. (2003) Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkB signalling.
Amount: 0.025 mg
Available: In stock
Listprice: €182.24
Price: €182.24
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