Antibodies

CD3

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 145-2C11
Applications FC
Amount 0.025 mg
ArtNr 20-783-310631
Available
Genway ID:
GWB-4E7AC0
Specificity:
CD3NCBI
Gene ID:
12501
Specificity:
CD3
Clone:
145-2C11
Immunogen:
H-2Kb - specific mouse cytoxic T lymphocyte clone BM10-37.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 2
Preservative Stabilisers:
0. 09%Sodium Azide (NaN3)1%Bovine Serum Albumin Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/).
Function:
The CD3 complex mediates signal transduction.
Subunit:
The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma delta epsilon zeta and eta.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Contains 1 Ig-like (immunoglobulin-like) domain.
Similarity:
Contains 1 ITAM domain. 1. Leo. O. et al. (1987) Identification of a monoclonal antibody specific for a murine T3 polypeptide. 2. Payer. E. et al. (1991) Circulating CD3+/T cell receptor V ³ 3+ fetal murine thymocytes home to the skin and give rise to proliferating dendritic epidermal T cells. J. Immunol. 146: 2536-2543. 3. Salvadori. S. et al. (1994) Abnormal signal transduction by T cells of mice with parental tumors is not seen in mice bearing IL-2-secreting tumors. 4. Tilley. S. L. et al. (2007) Retinoid-related orphan receptor ³ controls immunoglbulin production and the Th1/Th2 cytokine balance in the adaptive immune response to allergen. J. Immunol. 178: 3208-3218. 5. Podd. B. S. et al. (2006) T cells in cryptopatch aggregates share TCR ³ variable region junction sequences with ³ ´ T cells in the small intestinal epithelium of mice. J. Immunol. 176: 6532-6542.
Amount: 0.025 mg
Available: In stock
Listprice: €182.24
Discount: -10.0%
Price: €164.02
You save: €18.22
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