CD8 ALPHA

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 53-6. 7
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310648
Available
Genway ID:
GWB-8CE70D
Specificity:
CD8 ALPHANCBI
Gene ID:
12525
Specificity:
CD8 ALPHA
Clone:
53-6. 7
Immunogen:
Mouse thymus or spleen.
Immunohistology:
This product has been reported as working well on Zinc-fixed paraffin-embedded sections. However. inconsistent results have been reported on formalin-fixed paraffin-embedded tissue sections.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 2
Preservative Stabilisers:
0. 09%Sodium Azide (NaN3) Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/).
Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Subunit:
In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterdimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform 2: Secreted.
Ptm:
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers while the four N-terminal cysteines do not (By similarity).
Disease:
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells leading to recurrent bacterial infections.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Jabbari. A. and Harty. J. T. (2006) The generation and modulation of antigen-specific memory CD8 T cell responses. 2. Takahashi. K. et al. (1992) CD4 and CD8 regulate interleukin 2 responses of T cells.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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