CD44

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 156-3C11
Applications WB, FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310649
Available
Genway ID:
GWB-1E72D7
Specificity:
CD44
Specificity:
CD44
Clone:
156-3C11
Immunogen:
Stimulated human leucocytes.
Immunohistology:
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6. 0 is recommended for this purpose. Histology: Human Tonsil
Preparation:
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide (NaN3) Suggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/50 - 1/100Immunohistology - Frozen - 1/100Immunohistology - Paraffin - 1/100
Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA and possibly also through its affinity for other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration tumor growth and progression. Also involved in lymphocyte activation recirculation and homing and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Subunit:
Interacts with HA as well as other glycosaminoglycans collagen laminin and fibronectin via its N-terminal segment. Interacts with ANK the ERM proteins (VIL2 RDX and MSN) and NF2 via its C-terminal segment.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
Ptm:
Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors.
Ptm:
N-glycosylated.
Ptm:
O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans whose number may affect the accessibility of specific proteinases to their cleavage site(s).
Ptm:
Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site) and the phosphorylation of Ser-672.
Polymorphism:
CD44 is responsible for the Indian blood group system. The molecular basis of the In(A)=In1/In(B)=In2 blood group antigens is a single variation in position 46; In(B) the most frequent allele has Arg-46.
Similarity:
Contains 1 Link domain. 1. Denning. S. M. et al. (1995) AS10 CD44 and CD45R Cluster report. In Leucocyte Typing V. White cell differentiation antigens. Eds Schlossman. S. F. et al. Oxford University Press. Volume 2:1713 1719
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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