CD54

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 84H10
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310691
Available
Genway ID:
GWB-B857DF
Specificity:
CD54NCBI
Gene ID:
3383
Specificity:
CD54
Clone:
84H10
Immunogen:
K562 cell line
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the MOPC 315 mouse myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat - 1/10Immunohistology - Frozen - 1/20 - 1/50Immunoprecipitation - 5ug / 10& lt; sup& gt; 7& lt; /sup& gt; cells
Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
Subunit:
Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Ptm:
Monoubiquitinated which is promoted by MARCH9 and leads to endocytosis.
Polymorphism:
Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.
Similarity:
Belongs to the immunoglobulin superfamily. ICAM family.
Similarity:
Contains 5 Ig-like C2-type (immunoglobulin-like) domains. 1. Makgoba. M. W. et al. (1988) ICAM-1 is a ligand for LFA-1 dependent adhesion of B. T and myeloid cells. 2. Rothlein. R. et al. (1986) A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. 3. Dustin. M. L. et al. (1986) Induction by IL 1 and interferon-gamma: tissue distribution. biochemistry. and function of a natural adherence molecule (ICAM-1). 4. Damle. N. K. et al. (1992) Intercellular adhesion molecule-2. a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1). provides a costimulatory signal for T-cell receptor-initiated activation of human T cells 5. de Fougerolles. A. R. and Springer. T. A. (1992) Intercellular adhesion molecule 3. a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes 6. Simmons. D. et al. (1988) ICAM. an adhesion ligand of LFA-1. is homologous to the neural cell adhesion molecule NCAM. 7. Galkowska. H. et al. (1996) Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes. 8. Berendt. A. R. et al. (1992) The Binding Site on ICAM-1 for Plasmodium falciparum - Infected Erythrocytes Overlaps. but is Distinct from the LFA-1 - Binding Site.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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