CD54

GWB-B857DF

3383

84H10

Spleen cells from immunised BALB/c mice were fused with cells of the MOPC 315 mouse myeloma cell line.

Phosphate buffered saline pH7. 4

Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Membrane; Single-pass type I membrane protein.

Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.

Contains 5 Ig-like C2-type (immunoglobulin-like) domains. 1. Makgoba. M. W. et al. (1988) ICAM-1 is a ligand for LFA-1 dependent adhesion of B. T and myeloid cells. 2. Rothlein. R. et al. (1986) A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. 3. Dustin. M. L. et al. (1986) Induction by IL 1 and interferon-gamma: tissue distribution. biochemistry. and function of a natural adherence molecule (ICAM-1). 4. Damle. N. K. et al. (1992) Intercellular adhesion molecule-2. a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1). provides a costimulatory signal for T-cell receptor-initiated activation of human T cells 5. de Fougerolles. A. R. and Springer. T. A. (1992) Intercellular adhesion molecule 3. a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes 6. Simmons. D. et al. (1988) ICAM. an adhesion ligand of LFA-1. is homologous to the neural cell adhesion molecule NCAM. 7. Galkowska. H. et al. (1996) Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes. 8. Berendt. A. R. et al. (1992) The Binding Site on ICAM-1 for Plasmodium falciparum - Infected Erythrocytes Overlaps. but is Distinct from the LFA-1 - Binding Site.