Antibodies

CD8 ALPHA

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone KT15
Applications FC, IHC
Amount 0.025 mg
ArtNr 20-783-310700
Available
Genway ID:
GWB-A2421D
Specificity:
CD8 ALPHANCBI
Gene ID:
12525
Specificity:
CD8 ALPHA
Clone:
KT15
Immunogen:
T cell clone C6
Fusion Partner:
Spleen cells from immunised SD rats were fused with cells of the NSO mouse myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/50 - 1/100
Function:
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Subunit:
In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterdimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform 2: Secreted.
Ptm:
All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers while the four N-terminal cysteines do not (By similarity).
Disease:
Defects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells leading to recurrent bacterial infections.
Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain. 1. Tomonari. K. et al. (1988) T-cell receptor-specific monoclonal antibodies against a V beta 11 positive mouse T-cell clone. 2. Whiteland. J. L. et al. (1995) Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Price: €152.38
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