CD49d

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone HP2/1
Applications FC, IP, IHC
Amount 0.025 mg
ArtNr 20-783-310705
Available
Genway ID:
GWB-B1F12E
Specificity:
CD49dNCBI
Gene ID:
3676
Specificity:
CD49d
Clone:
HP2/1
Immunogen:
JM leukaemia line
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the X63 Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G.
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Dilution:
Suggested
Dilution:
Flow Cytometry - 1ug/5 x 10& lt; sup& gt; 5& lt; /sup& gt; cells
Function:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Domain:
The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Ptm:
Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Sanchez-Madrid. F. et al. (1986) VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization. 2. Weller. P. F. et al. (1991) Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1. 3. Mattila. P. et al. (1992) VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. 4. Kumagai. M. et al. (1995) The cross-reactivity of anti-human adhesion mAb with primate and swine cells. Leucocyte Typing V. Oxford University Press p. 1646-1648. 5. Sopper. S. et al. (1997) Lymphocyte subsets and expression of different markers in blood and lymphoid organs of rhesus monkeys. 6. Van Vliet. S. S. et al. (1995) Species cross reactivity (human-monkey-pig-bovine) of the adhesion structure section mAB. Leucocyte Typing V. Oxford University Press p 1607-1608. 7. Schmitz. J. et al. (2001) Simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys. 8. Sanz. M. et al. (1997) Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways. 9. Kuroda. M. et al. (1999) Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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