Comparison

CD49d

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone HP2/1
Applications FC, IP, IHC
Amount 0.025 mg
Item no. 20-783-310705
eClass 6.1 32160702
eClass 9.0 32160702
Available
Genway ID:
GWB-B1F12E
Specificity:
CD49dNCBI
Gene ID:
3676
Specificity:
CD49d
Clone:
HP2/1
Immunogen:
JM leukaemia line
Fusion Partner:
Spleen cells from immunised BALB/c mice were fused with cells of the X63 Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G.
Buffer Solution:
Phosphate buffered saline
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Dilution:
Suggested
Dilution:
Flow Cytometry - 1ug/5 x 10& lt; sup& gt; 5& lt; /sup& gt; cells
Function:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN LPXN and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Domain:
The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Ptm:
Phosphorylation on Ser-1027 inhibits PXN binding.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Sanchez-Madrid. F. et al. (1986) VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization. 2. Weller. P. F. et al. (1991) Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1. 3. Mattila. P. et al. (1992) VLA-4 integrin on sarcoma cell lines recognizes endothelial VCAM-1. Differential regulation of the VLA-4 avidity on various sarcoma cell lines. 4. Kumagai. M. et al. (1995) The cross-reactivity of anti-human adhesion mAb with primate and swine cells. Leucocyte Typing V. Oxford University Press p. 1646-1648. 5. Sopper. S. et al. (1997) Lymphocyte subsets and expression of different markers in blood and lymphoid organs of rhesus monkeys. 6. Van Vliet. S. S. et al. (1995) Species cross reactivity (human-monkey-pig-bovine) of the adhesion structure section mAB. Leucocyte Typing V. Oxford University Press p 1607-1608. 7. Schmitz. J. et al. (2001) Simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys. 8. Sanz. M. et al. (1997) Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways. 9. Kuroda. M. et al. (1999) Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.025 mg
Available: In stock
available

Delivery expected until 4/25/2024 

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