CD11b


Manufacturer	GENWAY
Category	Oncology Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer Oligodendrocyte Markers
Type	Antibody
Specific against	other
Clone	5C6
Applications	FC
Amount	25 TESTS
Item no.	20-783-310707
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-1BB6B0
Specificity:	CD11bNCBI
Gene ID:	16409
Specificity:	CD11b
Clone:	5C6
Immunogen:	Thioglycollate-elicted Peritoneal Macrophages (TPM)
Fusion Partner:	Spleen cells from AO rats were fused with cells of the Y3 rat myeloma cell line.
Preparation:	Purified IgG prepared by ion exchange chromatography
Buffer Solution:	Phosphate buffered saline pH 7. 2
Preservative Stabilisers:		0. 09%Sodium Azide1%Bovine Serum Albumin Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:	Flow Cytometry - 1/10
Function:	Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3 the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subunit:	Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Predominantly expressed in monocytes and granulocytes.
Domain:	The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Disease:	Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:	Belongs to the integrin alpha chain family.
Similarity:	Contains 7 FG-GAP repeats.
Similarity:	Contains 1 VWFA domain. 1. Rosen H and Gordon. S. (1990) The role of the Type 3 Complement Receptor in the induced recruitment of myelomonocytic cells to inflammatory sites in mouse.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 25 TESTS

available

Delivery expected until 5/30/2024