CD11b

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 5C6
Applications FC
Amount 25 TESTS
ArtNr 20-783-310707
Available
Genway ID:
GWB-1BB6B0
Specificity:
CD11bNCBI
Gene ID:
16409
Specificity:
CD11b
Clone:
5C6
Immunogen:
Thioglycollate-elicted Peritoneal Macrophages (TPM)
Fusion Partner:
Spleen cells from AO rats were fused with cells of the Y3 rat myeloma cell line.
Preparation:
Purified IgG prepared by ion exchange chromatography
Buffer Solution:
Phosphate buffered saline pH 7. 2
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - 1/10
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3 the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Disease:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats.
Similarity:
Contains 1 VWFA domain. 1. Rosen H and Gordon. S. (1990) The role of the Type 3 Complement Receptor in the induced recruitment of myelomonocytic cells to inflammatory sites in mouse.
Amount: 25 TESTS
Available: In stock
Listprice: €258.32
Discount: -10.0%
Price: €232.49
You save: €25.83
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