CD11b

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone M1/70. 15
Applications FC
Amount 0.025 mg
ArtNr 20-783-310713
Available
Genway ID:
GWB-35A89D
Specificity:
CD11bNCBI
Gene ID:
16409
Specificity:
CD11b
Clone:
M1/70. 15
Immunogen:
T cell enriched splenocytes from B10 mice
Fusion Partner:
Spleen cells from immunised DA rats were fused with cells of the NS1/1. Ag4. 1 mouse myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum AlbuminSuggested
Dilution:
Suggested
Dilution:
Flow Cytometry - Neat
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3 the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Disease:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats.
Similarity:
Contains 1 VWFA domain. 1. Springer. T. et al. (1978) Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. 2. Springer. T. et al. (1979) Mac-1: a macrophage differentiation antigen identified by a monoclonal antibody. 3. Beller. D. I. et al. (1982) Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor 4. Whiteland. J. L. et al. (1995) Immunohistochemical detection of T cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. 5. Klingel. K. et al. (2003) Beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis.
Amount: 0.025 mg
Available: In stock
Listprice: €168.20
Discount: -10.0%
Price: €151.38
You save: €16.82
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