Comparison

CD11b

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone M1/70. 15
Applications FC
Amount 25 TESTS
Item no. 20-783-310716
eClass 6.1 32160702
eClass 9.0 32160702
Available
Genway ID:
GWB-3B9D1F
Specificity:
CD11bNCBI
Gene ID:
16409
Specificity:
CD11b
Clone:
M1/70. 15
Immunogen:
T cells enriched splenocytes from B10 mice.
Fusion Partner:
Spleen cells from an immunised DA rat were fused with cells of the mouse NS1/1. Ag4. 1 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide1%Bovine Serum Albumin
Reconstitution: Reconstitute in 0. 25 ml disilled waterSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. This may be reduced by using SeroBlock FcR (/). Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3 the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.
Domain:
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Disease:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin joints kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats.
Similarity:
Contains 1 VWFA domain. 1. Springer. T. et al. (1978) Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. 2. Springer. T. et al. (1979) Mac-1: a macrophage differentiation antigen identified by a monoclonal antibody. 3. Beller. D. I. et al. (1982) Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor 4. Whiteland. J. L. et al. (1995) Immunohistochemical detection of T cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies. 5. Klingel. K. et al. (2003) Beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 TESTS
Available: In stock
available

Delivery expected until 4/25/2024 

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