Antibodies

CD51/CD61

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against other
Clone 23C6
Applications FC, IP
Amount 0.025 mg
ArtNr 20-783-310718
Available
Genway ID:
GWB-33249B
Specificity:
CD51/CD61NCBI
Gene ID:
3685
Specificity:
CD51/CD61
Clone:
23C6
Immunogen:
Osteoclasts from osteoclastomas
Fusion Partner:
Spleen cells from immunised mice were fused with cells of the mouse X63. Ag8. 653 myeloma cell line.
Preparation:
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - 1/40 - 1/80
Function:
The alpha-V integrins are receptors for vitronectin cytotactin fibronectin fibrinogen laminin matrix metalloproteinase-2 osteopontin osteomodulin prothrombin thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi\' s sarcoma lesions.
Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1 beta-3 beta-5 beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this virus (By similarity). Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the integrin alpha chain family.
Similarity:
Contains 7 FG-GAP repeats. 1. Horton. M. A. et al. (1985) Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. 2. Davies. J. et al. (1989) The osteoclast functional antigen. implicated in the regulation of bone resorption. is biochemically related to the vitronectin receptor. 3. Simpson. A. et al. (1989) Expression of the vitronectin receptor during embryonic development; an immunohistological study of the ontogeny of the osteoclast in the rabbit.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Price: €152.38
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