CD106


Manufacturer	GENWAY
Category	Oncology Neuroscience Neuroinflammation Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies By Organ Renal Cancer
Type	Antibody
Specific against	other
Clone	1. G11B1
Applications	FC
Amount	0.025 mg
Item no.	20-783-310737
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-3E64DE
Specificity:	CD106NCBI
Gene ID:	7412
Specificity:	CD106
Clone:	1. G11B1
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09%Sodium Azide0. 1%Bovine Serum AlbuminSuggested
Flow Cytometry:	Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:	Flow Cytometry - Neat - 1/10
Function:	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:	Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity).
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	Expressed on inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Induction:	By cytokines (e. g. IL-1 TNF-alpha).
Domain:	Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Ptm:	Sialoglycoprotein.
Disease:	May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
Similarity:	Contains 7 Ig-like C2-type (immunoglobulin-like) domains. 1. Thornhill. M. H. et al. (1991) Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T-cells. The contribution of vascular cell adhesion molecule-1-dependent and independent binding mechanisms. 2. Rosenman. S. J. et al. (1995) Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.

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Amount: 0.025 mg

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Delivery expected until 5/30/2024