CD106

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone 1. G11B1
Applications FC
Amount 0.025 mg
ArtNr 20-783-310737
Available
Genway ID:
GWB-3E64DE
Specificity:
CD106NCBI
Gene ID:
7412
Specificity:
CD106
Clone:
1. G11B1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09%Sodium Azide0. 1%Bovine Serum AlbuminSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul. Suggested
Dilution:
Flow Cytometry - Neat - 1/10
Function:
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit:
Binds to ECMV-D capsid proteins and acts as a receptor for this virus (By similarity).
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed on inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Induction:
By cytokines (e. g. IL-1 TNF-alpha).
Domain:
Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Ptm:
Sialoglycoprotein.
Disease:
May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
Similarity:
Contains 7 Ig-like C2-type (immunoglobulin-like) domains. 1. Thornhill. M. H. et al. (1991) Tumor necrosis factor combines with IL-4 or IFN-gamma to selectively enhance endothelial cell adhesiveness for T-cells. The contribution of vascular cell adhesion molecule-1-dependent and independent binding mechanisms. 2. Rosenman. S. J. et al. (1995) Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines.
Amount: 0.025 mg
Available: In stock
Listprice: €182.24
Discount: -10.0%
Price: €164.02
You save: €18.22
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