CD55

GWB-271742

1604

BRIC216

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Use 10ul of the suggested working dilution to label 106 cells in 100ul

Monomer (major form) and non-disulfide-linked covalent homodimer (minor form). Binds to coxsackievirus A21 coxsackieviruses B1 B3 and B5 human enterovirus 70 human echoviruses 6 7 11 12 20 and 21 capsid proteins and acts as a receptor for these viruses.

Isoform 2: Cell membrane; Lipid-anchor GPI-anchor.

The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).

Responsible for the Cromer blood group system. It consists of at least 8 high-incidence (Cr(a) Tc(a) Dr(a) Es(a) WES(b) UMC IFC and GUTI) and three low-incidence (Tc(b) Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF respectively. In the case of the Dr(a-) phenotype a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution Leu-199 that is the basis of the antigenic variation and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF but these individuals are not known to have any associated hematologic or other abnormalities.

Contains 4 Sushi (CCP/SCR) domains. 1. Coyne. K. E. et al. (1992) Mapping of epitopes. glycosylation sites. and complement regulatory domains in human decay accelerating factor.