Antibodies

CD55

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Clone BRIC216
Applications FC, IP
Amount 0.025 mg
ArtNr 20-783-310743
Available
Genway ID:
GWB-271742
Specificity:
CD55NCBI
Gene ID:
1604
Specificity:
CD55
Clone:
BRIC216
Immunogen:
Human fibroblast cell line
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Preservative Stabilisers:
0. 09%Sodium AzideSuggested
Flow Cytometry:
Use 10ul of the suggested working dilution to label 106 cells in 100ul
Function:
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb the amplification convertases of the complement cascade.
Subunit:
Monomer (major form) and non-disulfide-linked covalent homodimer (minor form). Binds to coxsackievirus A21 coxsackieviruses B1 B3 and B5 human enterovirus 70 human echoviruses 6 7 11 12 20 and 21 capsid proteins and acts as a receptor for these viruses.
Subcellular Location:
Isoform 1: Membrane; Single-pass type I membrane protein.
Subcellular Location:
Isoform 2: Cell membrane; Lipid-anchor GPI-anchor.
Tissue Specificity:
Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments and variants of the molecule are present in body fluids and in extracellular matrix.
Domain:
The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).
Ptm:
The Ser/Thr-rich domain is heavily O-glycosylated.
Polymorphism:
Responsible for the Cromer blood group system. It consists of at least 8 high-incidence (Cr(a) Tc(a) Dr(a) Es(a) WES(b) UMC IFC and GUTI) and three low-incidence (Tc(b) Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF respectively. In the case of the Dr(a-) phenotype a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution Leu-199 that is the basis of the antigenic variation and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF but these individuals are not known to have any associated hematologic or other abnormalities.
Similarity:
Belongs to the receptors of complement activation (RCA) family.
Similarity:
Contains 4 Sushi (CCP/SCR) domains. 1. Coyne. K. E. et al. (1992) Mapping of epitopes. glycosylation sites. and complement regulatory domains in human decay accelerating factor.
Amount: 0.025 mg
Available: In stock
Listprice: €152.38
Discount: -10.0%
Price: €137.14
You save: €15.24
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