MOUSE ANTI ATIC

Manufacturer GENWAY
Category
Type Antibody
Specific against other
Applications WB
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314650
Available
Genway ID:
GWB-97FFB5
Specificity:
ATIC
Isotype:
IgG1Species Cross Reactivity: Reacts with: Rat Mouse Drosophila Xenopus HumanN. B. Antibody reactivity and working conditions may vary between species.
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Ovalbumin-conuugated synthetic peptide AHTNLRLFHH
Specificity:
Specifically recognises ATIC otherwise known as AICAR a ribonucleotide formyltransferase (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) and member of the purH family which helps catalyze the final steps of the purine biosynthesis pathway. ATIC has been identified as an activator of AMP-activated protein kinase (AMPK) a known regulator of energy homeostasis inhibitor of cell proliferation and inducer of apoptosis in cancerous cells of various origins making ATIC a potential therapeutic agent for cancer. The anti-inflammatory and neuroprotective functions of ATIC also have implications for its use in the treatment of Alzheimer\' s disease. Recommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Ref. 14Catalytic activity10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
Pathway:
Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. Subunit structureHomodimer. Ref. 14Ref. 13
Domain:
The IMP cyclohydrolase activity resides in the N-terminal region. Involvement in diseaseDefects in ATIC are the cause of AICA-ribosuria [MIM:608688]; also known as AICA-ribosiduria. AICA-ribosuria is a neurologically devastating inborn error of purine biosynthesis. AICA-ribosuria patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA-ribotide and its derivatives in erythrocytes and fibroblasts. AICA-ribosuria causes profound mental retardation epilepsy dysmorphic features and congenital blindness. Ref. 15Sequence similaritiesBelongs to the purH family. [1] \" Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. \" Chaudhary P. M. Ferguson C. Nguyen V. Nguyen O. Massa H. F. Eby M. Jasmin A. Trask B. J. Hood L. Nelson P. S. Blood 91:4020-4027(1998) [PubMed: 9596645] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANTS LEU-616 AND LEU-822. Tissue: Leukocyte and Prostate. [2] \" Homo sapiens TLR5. \" Seya T. Tsukada H. Submitted (APR-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT LEU-822. Tissue: Macrophage. [3] \" Natural selection in the TLR-related genes in the course of primate evolution. \" Nakajima T. Ohtani H. Satta Y. Uno Y. Akari H. Ishida T. Kimura A. Immunogenetics 60:727-735(2008) [PubMed: 18810425] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT LEU-822. [4] \" A history of recurrent positive selection at the toll-like receptor 5 in primates. \" Wlasiuk G. Khan S. Switzer W. M. Nachman M. W. Mol. Biol. Evol. 26:937-949(2009) [PubMed: 19179655] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT LEU-822. [5] \" The DNA sequence and biological annotation of human chromosome 1. \" Gregory S. G. Barlow K. F. McLay K. E. Kaul R. Swarbreck D. Dunham A. Scott C. E. Howe K. L. Woodfine K. Spencer C. C. A. Jones M. C. Gillson C. Searle S. Zhou Y. Kokocinski F. McDonald L. Evans R. Phillips K. Atkinson A. Cooper R. Jones C. Hall R. E. Andrews T. D. Lloyd C. Ainscough R. Almeida J. P. Ambrose K. D. Anderson F. Andrew R. W. Ashwell R. I. S. Aubin K. Babbage A. K. Bagguley C. L. Bailey J. Beasley H. Bethel G. Bird C. P. Bray-Allen S. Brown J. Y. Brown A. J. Buckley D. Burton J. Bye J. Carder C. Chapman J. C. Clark S. Y. Clarke G. Clee C. Cobley V. Collier R. E. Corby N. Coville G. J. Davies J. Deadman R. Dunn M. Earthrowl M. Ellington A. G. Errington H. Frankish A. Frankland J. French L. Garner P. Garnett J. Gay L. Ghori M. R. J. Gibson R. Gilby L. M. Gillett W. Glithero R. J. Grafham D. V. Griffiths C. Griffiths-Jones S. Grocock R. Hammond S. Harrison E. S. I. Hart E. Haugen E. Heath P. D. Holmes S. Holt K. Howden P. J. Hunt A. R. Hunt S. E. Hunter G. Isherwood J. James R. Johnson C. Johnson D. Joy A. Kay M. Kershaw J. K. Kibukawa M. Kimberley A. M. King A. Knights A. J. Lad H. Laird G. Lawlor S. Leongamornlert D. A. Lloyd D. M. Loveland J. Lovell J. Lush M. J. Lyne R. Martin S. Mashreghi-Mohammadi M. Matthews L. Matthews N. S. W. McLaren S. Milne S. Mistry S. Moore M. J. F. Nickerson T. O\' Dell C. N. Oliver K. Palmeiri A. Palmer S. A. Parker A. Patel D. Pearce A. V. Peck A. I. Pelan S. Phelps K. Phillimore B. J. Plumb R. Rajan J. Raymond C. Rouse G. Saenphimmachak C. Sehra H. K. Sheridan E. Shownkeen R. Sims S. Skuce C. D. Smith M. Steward C. Subramanian S. Sycamore N. Tracey A. Tromans A. Van Helmond Z. Wall M. Wallis J. M. White S. Whitehead S. L. Wilkinson J. E. Willey D. L. Williams H. Wilming L. Wray P. W. Wu Z. Coulson A. Vaudin M. Sulston J. E. Durbin R. M. Hubbard T. Wooster R. Dunham I. Carter N. P. McVean G. Ross M. T. Harrow J. Olson M. V. Beck S. Rogers J. Bentley D. R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [6] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [7] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT LEU-822. [8] \" A family of human receptors structurally related to Drosophila Toll. \" Rock F. L. Hardiman G. Timans J. C. Kastelein R. A. Bazan J. F. Proc. Natl. Acad. Sci. U. S. A. 95:588-593(1998) [PubMed: 9435236] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 494-858 VARIANT LEU-822. Tissue: CNS. [9] \" Signal peptide prediction based on analysis of experimentally verified cleavage sites. \" Zhang Z. Henzel W. J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]Cited for: PROTEIN SEQUENCE OF 21-35. [10] \" The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. \" Hayashi F. Smith K. D. Ozinsky A. Hawn T. R. Yi E. C. Goodlett D. R. Eng J. K. Akira S. Underhill D. M. Aderem A. Nature 410:1099-1103(2001) [PubMed: 11323673] [Abstract]Cited for: FUNCTION.
Amount: 0.1 mg
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