MOUSE ANTI RAT CD49d:FITC

CD49d

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Specifically recognises rat CD49d otherwise known as integrin alpha 4 chain/VLA-4 a 150kDa type-1 transmembrane glycoprotein and member of the integrin alpha chain family which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes monocytes thymocytes mast cells and dendritic cells and is involved in cell-cell interactions mononuclear cell trafficking to sites of endothelial inflammation and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitro and in vivo functions of CD49d(1). Studies have shown that in rat Peyer\' s patches clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV) and significantly inhibits the transendothelial migration of T lymphocytes(2). Recommended for functional studies. Recommended Negative Controls: MOUSE IgG2a NEGATIVE CONTROL:FITC