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Deltarasin

Deltarasin

Item no.	HY-15747-50mg
Manufacturer	MedChem Express
CASRN	1440898-61-2
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 2 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.12
Citations	[1]Zimmermann G, et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 2013 May 30;497(7451):638-42.\|[2]Agalioti T, et al. Mutant KRAS promotes malignant pleural effusion formation. Nat Commun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.
Smiles	C1(C2=CC=C(OC[C@@H](N3C4=CC=CC=C4N=C3C5=CC=CC=C5)C6CCNCC6)C=C2)=NC7=CC=CC=C7N1CC8=CC=CC=C8
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1440898-61-2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Phosphodiesterase (PDE); Ras
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	603.75
Product Description	Deltarasin is an inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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