EZ-482

Item no.	CS-0023792-25mg
Manufacturer	ChemScene
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1016456-76-0
Similar products	1016456-76-0
Available
CAS	1016456-76-0
Purity	>98%
MWt	498.94
Formula	C23H19ClN4O5S
Solubility	DMSO : 83.33 mg/mL (167.01 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Others
Target	Others
Biological Activity	EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with K_ds of 5-10 uM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer's diseas^[1]. IC50 & Target: Kd: 5-10 uM (apoE3 and apoE4)^[1] In Vitro: EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265^[1]. EZ-482 (0.5, 1, 5, 10 uM; 1 hour) blocks heparin binding in a concentration-dependent manner^[1].
Research Area	Neurological Disease

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Amount: 25mg

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