RO5 Drug-like Natural Product Library

Natural products are important sources of lead compounds and drug candidates. They have complex scaffold structures and rich functional groups. Their structures are unique, and most of them are chiral. These naturally occurring advantages provide more diverse options for the transformation of natural products into drugs, and are also the reasons why natural products play an important role in drug development and research. Based on the structural diversity and novelty of natural products, TargetMol used the druglikeness prediction index "Lipinski's Rule of Five" to select 2, 253 natural product monomers with good druggabilities, covering diverse structures from vast sources such as terpenes and alkaloids. The library is consisted of monomers with both biological activity and drug-like properties. It is a powerful tool for subsequent structure-effect optimization and innovative drug research.