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Aminopterin

Aminopterin

Manufacturer	MedChem Express
Category	Peptides Peptides general
Type	Peptides
Specific against	other
Amount	100mg
Item no.	HY-14518-100mg
CASRN	54-62-6
Available
Product Description	Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.
StorageTemperature	Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Applications	Cancer-programmed cell death
Formula	C19H20N8O5
References	[1].MEYER LM, et al. Aminopterin, a folic acid antagonist, in the treatment of leukemia. Am J Clin Pathol. 1949 Feb; 19(2):119-26. \| [2].Gebhardt DO, et al. The influence of aminopterin on limb regeneration in Ambystoma mexicanum. J Embryol Exp Morphol. 1966 Aug; 16(1):143-58. \| [3].Rosowsky A, et al. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem. 2004 Dec 30; 47(27):6958-63. \| [4].F. W Gtmrz, et al. THE EFFECT OF 4-AMINO-PTEROYLGLUTAMIC ACID (AMINOPTERIN) ON HUMAN LEUKEMIC LEUKOCYTES IN VITRO. Blood (1950) 5 (2): 161-166.
MolecularWeight	440.41
Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 14.71 mg/mL (33.40 mM; Need ultrasonic) \| H2O : 5 mg/mL (11.35 mM; ultrasonic and adjust pH to 8 with NaOH)
Target	Antifolate
Pathway	Cell Cycle/DNA Damage

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Amount: 100mg

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Delivery expected until 4/20/2023

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