Comparison

Recombinant Mouse Dkk-1 Protein

Manufacturer Abclonal
Category
Specific against other
Amount 10 ug
Item no. RP01350LQ-10ug
Available
Remarks (NCBI alias)
DKK1
GeneID(Human)
DKK1
Route
C-His
Imminogen
Thr32-His272
Storage
This product is stable at ≤ -70°C for up to 1 year from the date of receipt.|For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature.
BackGround
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK1 takes part in embryonic development through its inhibition of the WNT signaling pathway, binds to LRP6 with high affinity and prevents the Frizzled-Wnt-LRP6 complex formation in response to Wnts. DKK1 promotes LRP6 internalization and degradation when it forms a ternary complex with the cell surface receptor Kremen.DKK1 not olny functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and multiple myeloma. More recently research reported, DKK1 impacts eye development from a defined developmental time point on, and is critical for lens separation from the surface ectoderm via β-catenin mediated Pdgfrα and E-cadherin expression.
RecommandDilutionA
Supplied as a 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 10% glycerol, pH8.0.
GeneSymbol
DKK1
ProteinFormulation
Supplied as a 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 10% glycerol, pH8.0.
ProteinDescription
Recombinant Mouse Dkk-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr32-His272) of mouse DKK-1 (Accession #NP_034181.2) fused with a 6×His tag at the C-terminus.
AntigenSeq
TLNSVLINSNAIKNLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGSDEYCSSPSRGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHFPRGEIEESIIENLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAAGLCCARHFWSKICKPVLKEGQVCTKHKRKGSHGLEIFQRCYCGEGLACRIQKDHHQASNSSRLHTCQRH

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
available

Delivery expected until 7/27/2023 

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