Comparison

IL-18 Protein, Mouse European Partner

Manufacturer MedChem Express
Category
Type Proteins Recombinant
Specific against other
Amount 10 ug
Item no. HY-P73181-10ug
eClass 6.1 34160400
eClass 9.0 42020190
Available
Product Description
IL-18 Protein, a pro-inflammatory cytokine, crucially participates in epithelial barrier repair and immune response modulation by polarizing T-helper 1 (Th1) cells and natural killer (NK) cells. Upon binding to IL18R1 and IL18RAP receptors, IL-18 forms a signaling ternary complex activating NF-kappa-B, inducing inflammatory mediators. It synergizes with IL-12 to stimulate IFNG synthesis from Th1 cells and NK cells. IL-18 is also involved in transducing inflammation during pyroptosis, with its mature form released through the gasdermin-D (GSDMD) pore. At the plasma membrane, IL-18 forms a ternary complex with IL18R1 and IL18RAP, signaling within the cell. Additionally, IL-18 interacts with the cargo receptor TMED10 for secretion from the cytoplasm to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). IL-18 Protein, Mouse is the recombinant mouse-derived IL-18 protein, expressed by E. coli, with tag free. The total length of IL-18 Protein, Mouse is 157 a.a., with molecular weight of ~19 kDa.
StorageTemperature
Stored at -80°C for 1 year
Shipping
Dry Ice
Molecular Weight
Approximately 19 kDa
Manufacturers Product type
Recombinant Proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
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