Recombinant human NEU-1/Sialidase-1 protein

Proteins

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

NEu1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A. Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red -myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. Recombinant human NEu1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Metabolism

Human

NEU1, Sialidase1, Sialidase 1 (lysosomal sialidase), NANH, NEu, SIAL1, ATGP1685-10ug, ATGP1685-20ug, ATGP1685-50ug, ATGP1685-100ug, ATGP1685-250ug, ATGP1685-500ug, ATGP1685-1mg, ATGP1685-10, ATGP1685-20, ATGP1685-50, ATGP1685-100, ATGP1685-250, ATGP1685-500, ATGP1685-1