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Human TOP2A / TOP2 Protein, Tag Free

Human TOP2A / TOP2 Protein, Tag Free

Item no.	TOA-H5117-500ug
Manufacturer	ACROBiosystems
Amount	500 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	E.coli
Conjugate/Tag	Unconjugated
Purity	90%
Dry ice	Yes
Citations	(1) Beser A R, Tuzlali S, Guzey D, et al. HER-2, TOP2A and chromosome 17 alterations in breast cancer.[J]. Pathology & Oncology Research, 2007, 13(3):180-185. (2) Vang Nielsen K, Ejlertsen B, M?Ller S, et al. The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D[J]. Acta Oncologica, 2008, 47(4):725-734.
NCBI	NP_001058.2
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TOP2A,TOP2,DNA topoisomerase 2-alpha,DNA topoisomerase II,alpha isozyme
Shipping Condition	Dry ice
Available
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	Native, Unconjugated
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	13.0 kDa
Manufacturer - Format	Liquid
Description	DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.
Background	DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.
Molecule	TOP2A
Exp Region	Ser 1354 - Ser 1473
Characteristics	This protein carries no "tag". The protein has a calculated MW of 13.0 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 0.5 M KCl, pH8.0
Stability	● The product MUST be stored at -70°C or lower upon receipt ● -70°C for 3 months under sterile conditions.
Protectant	glycerol

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

TOA-H5117-500ug-datasheet.pdf

TOA-H5117-500ug-safety-datasheet.pdf