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Anti-Propionyl-Histone H2A (Lys125) Rabbit mAb

Anti-Propionyl-Histone H2A (Lys125) Rabbit mAb

Item no.	PTM-217RM
Manufacturer	PTM Biolabs
Amount	100 ul
Format	Lyophilized powder
Applications	WB, CHIP
Clone	PA-076-08
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Alias	H2AK125pr
Shipping condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Histone & Histone Modification Antibodies
Manufacturer - Targets	Histone H2A
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	14
Manufacturer - Research Area	Epigenetics
Purification Method	Protein A purified
Manufacturer - Specificity	Anti-Propionyl-Histone H2A (Lys125) Rabbit mAb detects histone H2A only when it is propionylated at Lys125, but not the crotonylated and unmodified H2A peptide at Lys125.
Constituents	PBS, Glycerol, BSA
PTM	Propionyl
Modification Site	Lys125
Immunogen	Propionylated human histone H2A (Lys125) peptide
Clonality	Recombinant Monoclonal
Stability	Stable for 12 months from date of receipt/reconstitution.
Background	Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Lysine propionylation (Kprop) is structurally similar to lysine acetylation, is a newly identified reversible modification controlling protein activity. Lysine propionylation is abundant in both prokaryotes and eukaryotes and has been found in wide ranges of proteins including histones and non-histone substrates, such as p53. Similar to acetylation of histone H3 at Lys12, propionylation of histone H2A at Lys125 may play a vital role in the epigenetic modulation, including chromatin remodeling and transcriptional regulation.
Cellular Localization	Nucleus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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