Anti-Butyryl-Histone H2B (Lys23) Rabbit mAb

Histone & Histone Modification Antibodies

Ambient temperature

14

Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys23 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.

Anti-Butyryl-Histone H2B (Lys23) Rabbit mAb detects histone H2B only when it is butyrylated at Lys23. 

Butyryl

Butyrylated human histone H2B (Lys23) peptide

Stable for 12 months from date of receipt/reconstitution.

Nucleus