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Anti-Crotonyl-Histone H3 (Lys18) Rabbit mAb

Anti-Crotonyl-Histone H3 (Lys18) Rabbit mAb

Item no.	PTM-517RM
Manufacturer	PTM Biolabs
Amount	100 ul
Applications	WB, ICC
Clone	B1169344-H1L1
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Alias	H3K18cr
Shipping condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Histone & Histone Modification Antibodies
Manufacturer - Targets	Histone H3
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	15
Manufacturer - Research Area	Epigenetics
Purification Method	Protein A purified
Manufacturer - Specificity	This antibody detects histone H3 only when it is crotonylated at Lys18, but not the H3 peptide crotonylatd at Lys14 and Lys23; the H3 peptide acetylated, butyrylated or propinylated at Lys14, Lys18 and Lys23 and the unmodified peptide at Lys23.
Constituents	PBS, Glycerol, BSA
PTM	Crotonyl
Modification Site	Lys18
Immunogen	Crotonylated human histone H3 (Lys18) peptide
Clonality	Recombinant Monoclonal
Stability	Stable for 12 months from date of receipt/reconstitution.
Background	Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc.Crotonylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine crotonylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine crotonylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and mouse male germ cell genomes, histone crotonylation marks either active promoters or potential enhancers. Crotonylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation.
Cellular Localization	Nucleus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/27/2024

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