Anti-Phospho-AMPK beta 1 (Ser182) Rabbit pAb

Primary Antibodies

AMPK beta 1

Store at -20°C. Avoid freeze/thaw cycles.

AMPKβ1 is the β1 regulating subunit of AMP-activated protein kinase. It is post-translationally modified by myristoylation and multi-site phosphorylation including Ser24/25, Ser96, Ser101, Ser108, and Ser182. Phosphorylation at Ser108 of the β1 subunit seems to be required for AMPK activation, while phosphorylation at Ser24/25 and Ser182 affects AMPK localization. Several mutations in AMPKγ subunits have been identified, most of which are located in the putative AMP/ATP binding sites (CBS or Bateman domains). Mutations at these sites lead to reduction of AMPK activity and cause glycogen accumulation in heart or skeletal muscle. Accumulating evidence indicates that AMPK not only regulates the metabolism of fatty acids and glycogen, but also modulates protein synthesis and cell growth through EF2 and TSC2/mTOR pathways, as well as blood flow via eNOS/nNOS.

PBS, Glycerol, BSA

Ser182

Stable for 12 months from date of receipt/reconstitution.

Cell nucleus and cytosol