Anti-AGR2 Mouse mAb

Primary Antibodies

AGR2

Store at -20°C. Avoid freeze/thaw cycles.

Anterior gradient homolog 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family of proteins and a homolog of the Xenopus laevis cement gland protein. In normal human tissues, AGR2 is expressed most abundantly in intestinal cells. Research studies have found AGR2 is overexpressed in a number of adenocarcinomas, including those derived from breast, pancreas, ovary, prostate and esophagus. In vitro and in vivo studies have shown that AGR2 positively regulates cell growth and division, while its overexpression can promote cell transformation. The latter functions of AGR2 were shown to involve YAP1-mediated up-regulation of amphiregulin expression, implicating AGR2 in both the EGF and Hippo kinase signaling pathways.

PBS, Glycerol, BSA

Recombinant Monoclonal

Anterior gradient homolog 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family of proteins and a homolog of the Xenopus laevis cement gland protein. In normal human tissues, AGR2 is expressed most abundantly in intestinal cells. Research studies have found AGR2 is overexpressed in a number of adenocarcinomas, including those derived from breast, pancreas, ovary, prostate and esophagus. In vitro and in vivo studies have shown that AGR2 positively regulates cell growth and division, while its overexpression can promote cell transformation. The latter functions of AGR2 were shown to involve YAP1-mediated up-regulation of amphiregulin expression, implicating AGR2 in both the EGF and Hippo kinase signaling pathways.