Anti-IL-22 Rabbit pAb

Primary Antibodies

IL-22

Store at -20°C. Avoid freeze/thaw cycles.

Interleukin-22 (IL-22), a member of the IL-10 family, is expressed by Th17 CD4+ T cells, activated T cells, Th1 cells, and NK cells. IL-22 induces proinflammatory responses, drives production of antimicrobial peptides, and is involved in tissue repair and wound healing responses. The IL-22 receptor is a heterodimer of IL-22R1 and IL-10R2. Expression of IL-22R is restricted to tissue-resident cells, particularly those of epithelial origin, whereas the IL-10R2 chain is expressed in many more cell types. IL-22 induces phosphorylation of Jak1 and Tyk2, leading to activation of Stat3 and, to a lesser extent, Stat1 and Stat5. IL-22 responses can involve activation of the MEK-ERK-RSK, JNK-SAPK, and p38 pathways. Elevated levels of IL-22 have been associated with Crohn's disease and rheumatoid arthritis. IL-22 plays an essential role in host response to the pulmonary pathogen Klebsiella pneumoniae.

PBS, Glycerol, BSA

Polyclonal

Interleukin-22 (IL-22), a member of the IL-10 family, is expressed by Th17 CD4+ T cells, activated T cells, Th1 cells, and NK cells. IL-22 induces proinflammatory responses, drives production of antimicrobial peptides, and is involved in tissue repair and wound healing responses. The IL-22 receptor is a heterodimer of IL-22R1 and IL-10R2. Expression of IL-22R is restricted to tissue-resident cells, particularly those of epithelial origin, whereas the IL-10R2 chain is expressed in many more cell types. IL-22 induces phosphorylation of Jak1 and Tyk2, leading to activation of Stat3 and, to a lesser extent, Stat1 and Stat5. IL-22 responses can involve activation of the MEK-ERK-RSK, JNK-SAPK, and p38 pathways. Elevated levels of IL-22 have been associated with Crohn's disease and rheumatoid arthritis. IL-22 plays an essential role in host response to the pulmonary pathogen Klebsiella pneumoniae.