Anti-Histone H2A.Z Rabbit mAb

Primary Antibodies

Histone H2A.Z

Store at -20°C. Avoid freeze/thaw cycles.

H2A.Z is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2A.Z may be involved in the formation of constitutive heterochromatin. H2A.Z may be required for chromosome segregation during cell division.

PBS, Glycerol, BSA

Recombinant Monoclonal

H2A.Z is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2A.Z may be involved in the formation of constitutive heterochromatin. H2A.Z may be required for chromosome segregation during cell division.