Comparison

Anti-GIRK2 Rabbit mAb

Item no. PTM-7103
Manufacturer PTM Biolabs
Amount 100 ul
Format Lyophilized powder
Applications WB
Clone JRMR-10433-48
Specific against Mouse (Murine, Mus musculus)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
Alias KCNJ6, inwardly rectifying subfamily J member 6
Shipping condition Room temperature
Available
Manufacturer - Type
Primary Antibodies
Manufacturer - Category
Uncategorized
Manufacturer - Targets
GIRK2
Shipping Temperature
Ambient temperature
Storage Conditions
Store at -20°C. Avoid freeze/thaw cycles.
Manufacturer - Research Area
Neuroscience
Product description
GIRK2 is a member of G protein-coupled inwardly rectifying potassium channel family proteins (GIRKs). GIRK family proteins allow potassium to flow into the cell and therefore control cellular excitability in the central nervous system, heart, and pancreas. Activation of most GIRK channels requires heterologous subunit assembly and the presence of ATP. GIRK2 is abundantly expressed in the brain, where it is involved in pain perception. It is also required for peripheral opioid-mediated analgesia. Additionally GIRK2 localizes to pancreatic β cells and regulates insulin secretion. Mutations in the KCNJ6 gene encoding GIRK2 are associated with Keppen-Lubinsky Syndrome, a rare disease characterized by severe developmental delay, facial dysmorphism, and intellectual disability.
Purification Method
Protein A purified
Constituents
PBS, Glycerol, BSA
PTM
Unmodified
Clonality
Recombinant Monoclonal
Stability
Stable for 12 months from date of receipt/reconstitution.
Background
GIRK2 is a member of G protein-coupled inwardly rectifying potassium channel family proteins (GIRKs). GIRK family proteins allow potassium to flow into the cell and therefore control cellular excitability in the central nervous system, heart, and pancreas. Activation of most GIRK channels requires heterologous subunit assembly and the presence of ATP. GIRK2 is abundantly expressed in the brain, where it is involved in pain perception. It is also required for peripheral opioid-mediated analgesia. Additionally GIRK2 localizes to pancreatic β cells and regulates insulin secretion. Mutations in the KCNJ6 gene encoding GIRK2 are associated with Keppen-Lubinsky Syndrome, a rare disease characterized by severe developmental delay, facial dysmorphism, and intellectual disability.
Cellular Localization
Cell membrane

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
available

Delivery expected until 1/3/2025 

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