PERK Antibody

PERK Antibody is a Rabbit Polyclonal antibody against PERK. PERK (protein kinase-like endoplasmic reticulum kinase) is an eIF2alpha kinase and transmembrane protein resident in the endoplasmic reticulum (ER) membrane that couples ER stress signals to translation inhibition (1-3). ER stress increases the activity of PERK, which then phosphorylates eIF2alpha to promote reduced translation. PERK-deficient mice have defects in pancreatic beta cells several weeks after birth, suggesting a role for PERK-mediated translational control in protecting secretory cells from ER stress (4). PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain (1-3). Phosphorylation of PERK at Thr980 serves as a marker for its activation status.

Image Legend: Fig. 1. Western blot analysis of extracts of MCF7 cell line, using PERK antibody.

Unconjugated

Affinity purified.

Q9NZJ5

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This product is for research use only.