Vergleich
Antibodies

SIRT6 Antibody Europäischer Partner

ArtNr abx001167-200
Hersteller Abbexa
Menge 200 ul
Typ Antibody Primary
Applikationen WB, IHC
Specific against Human, Mouse, Rat
Host Rabbit
Isotype IgG
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products SIRT6
Lieferbar
Origin
Human
Description
SIRT6 Antibody is a Rabbit Polyclonal antibody against SIRT6. SIRT6, also named as SIR2L6, belongs to the sirtuin family. SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. It has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. It is required for genomic stability. And it is required for normal IGF1 serum levels and normal glucose homeostasis. It modulates cellular senescence and apoptosis. It regulates the production of TNF protein. SIRT6 acts as a histone deacetylase to directly repress multiple glycolytic genes. SIRT6 also functions as a corepressor of the transcription factor Hif1alpha. Loss of SIRT6 increases glycolysis and diminishes mitochondrial respiration. SIRT6 plays a key role in regulating glucose homeostasis.

Image Legend: Fig. 1. Western blot analysis of A431 cell lysate using SIRT6 antibody.
Antigen
SIRT6
Conjugation
Unconjugated
Immunogen
Recombinant fusion protein of human SIRT6.
Purification
Affinity purified.
Storage
Aliquot and store at -20 C. Avoid repeated freeze/thaw cycles.
Swiss Prot
Q8N6T7
Molecular Weight
36 kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Lead Time
Shipped within 5-10 working days.
Note
This product is for research use only.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 200 ul
Lieferbar: Out of stock
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