p38 (phospho Thr180/Y182) Polyclonal Antibody

Q16539

Mitogen-activated protein kinase 14 encoded by MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Mitogen-activated protein kinase 14 is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with mitogen-activated protein kinase 14.The substrates of mitogen-activated protein kinase 14 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of mitogen-activated protein kinase 14 in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of MAPK14 encoding distinct isoforms have been reported.

1 mg/ml

Liquid solution

Synthesized peptide derived from human p38 around the phosphorylation site of T180/Y182

Phospho-p38 (T180/Y182) Polyclonal Antibody detects endogenous levels of p38 protein only when phosphorylated at T180/Y182.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Stable for one year at -20C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.