ASC Polyclonal Antibody

Q9ULZ3

PYCARD encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein (PYD and CARD domain containing) is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for PYCARD.

1 mg/ml

Liquid solution

Synthesized peptide derived from the N-terminal region of human ASC at AA range: 10-90

ASC Polyclonal Antibody detects endogenous levels of ASC protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Stable for one year at -20C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.