Mouse IL-13 protein

Measured in a cell proliferation assay using TF1 human erythroleukemic cells (Kitamura, T. et al. (1989) J. Cell Physiol. 140:323.).
The ED50 for this effect is typically 2-10 ng/mL.

Human Cells

Lyophilized from sterile PBS, pH 7.5

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse IL13 protein in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.

The product is shipped at ambient temperature.

Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Ralpha) and at least one of two known IL-13-specific binding chains (IL-13 Ralpha1 and IL-13 Ralpha2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.

Il-13; Interleukin-13; IL13

P20109